WORKPACKAGE 1

Thorough analysis of animal models with mutant BBS, OFD1, or NPHP proteins

Leader of the WP is Brunella Franco from the Telethon Institute of Genetics and Medicine (Naples, Italy).

Taking advantage of the diverse animal models generated within EUCILIA, this consortium will perform a comparative analysis of the phenotypes caused by deletion of BBS, OFD1, and NPHP proteins in mice, Xenopus and zebrafish. This WP will deliver a comprehensive list of phenotypes that are shared between divergent animal species.